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We provide your lab with the most valuable information about your nanomaterials that can help you control the quality of your products. We count with the most advanced equipment and technology to fully analyse all the physical and chemical properties of your interest. Characterization allows the prediction of the behaviour of the nanomaterials like long term stability or in vivo distribution.


Drug Loading

 Size and distribution

Morphology analysis

Particle surface charge

Particle concentration

Entrapment efficiency


Size and size distribution

Determined using Dynamic Light Scattering (DLS) or Nanoparticle Tracking Analysis (NTA). The information provided by those techniques is the mean size and size distribution of the particles in suspension, whether they are nanovesicles, polymeric and inorganic nanoparticles, exosomes, or other nanostructures. It is a crucial parameter that influences its performance in in vivo treatments and thus therapeutic effectiveness as a result.

Among other processes it affects:

In vivo distribution

Organ and organelle accumulation and uptake

Renal and liver clearance

Drug loading capacity

Particle surface charge

Also referred to as Z-potential, is defined as the difference between the charge of the nanoparticle surface and the dispersion it is within. It measures the degree of repulsion between the nanoparticles, and consequently the likelihood of aggregation. It can be used as a:

Predictor of long-term stability

Assessment of coating effectiveness

Indicator of potential cell adhesion

Particle concentration

By means of Nanoparticle Tracking Analysis (NTA) particle concentration can be measured in real time. Like the size, particle concentration is an important factor to be considered for the following reasons:

  Toxicological problems

 Drug delivery efficiency

Regulatory requirements

In the case of exosomes, it may be linked to disease

Morphology analysis

Proper morphology plays an important role for the correct performance of the nanoparticles. The structural information can be obtained with various techniques like:

Transmission electron microscopy (TEM)

High resolution transmission electron microscopy (HR-TEM)

Scanning electron microscopy (SEM)

Drug loading capacity

The drug loading capacity is the amount of the active principle that is encapsulated per weight of nanocarrier. Depending on the application and type of active principle, it may need to be adjusted to reduce the toxicity of the drug or modify the speed of delivery.
This can be done by modifying the components ofthe nanoparticle. It can be measured by different techniques as UV-visible spectrophotometry or highperformance liquid chromatography.

Entrapment efficiency

The entrapment or encapsulation efficiency is the amount of product that has been successfully entrapped by the nanovesicles. The higher the encapsulation efficiency the less product that is been lost resulting in lower financial costs.


Zetasizer ZS90
(Malvern Instruments)

Nanosight LM10
(Malvern Panalytical)


Synergy HTX Multimode Microplate Reader

Other instruments we have access to:

Transmission Electron

Scanning Electron

Laer Scanning
Confocal Microscope