• Metallic nanoparticles

    Metallic nanoparticles have received great attention in the last few decades among the scientific community as extraordinary drug delivery systems. Apart from carrying drugs bonded onto their surface, they can be antibacterial and antitumoral and are exceptional tracking tools compatible with many techniques. Specifically, gold nanoparticles are an ideal drug delivery scaffold since they are known to be nontoxic and nonimmunogenic. In addition, they can be readily functionalized with multiple targeting molecules and have so far shown excellent potential for the delivery of multiple drugs.

KEY BENEFITS

  • Wide range of sizes, shapes and surface properties Tunable optical properties Easily surface modification
  • Drugs can be encapsulated within the nanoparticles or attached to the surface. They are osmotically active and stable. Improve the therapeutic performance of the drug by protecting it from the biological environment. They increase the stability of the entrapped drug
  • Good solubilization power
  • Increased stability due to the surface electric charge Exhibit good colloidal, chemical and biological stability.
  • Can increase the oral bioavailability of drugs Can enhance the skin penetration of drugs They can be used for oral, parenteral as well topical.
  • They are biodegradable, biocompatible, and non-immunogenic. Good biocompatibility

SOME EXAMPLES

  • Imaging and tracking: Recently, the biomedical imaging applications of gold nanoparticles have drawn tremendous interest owing to their desirable size and tunable optical properties. The use of GNPs in biomedical imaging techniques such as X-ray computed tomography, photo-acoustic imaging, dark field microscopic imaging, magnetic resonance imaging, and fluorescence imaging is very popular.
  • Controlled drug delivery: The release of the therapeutics agents in gold nanoparticles could be triggered by internal (Glutathione-mediated), pH or external (light) stimuli.
  • Bio-sensing: The use of gold nanoparticles-based sensing techniques could be a game changer in the biosensing applications. So far, gold nanopartices have been used for efficient colorimetric, electrochemical, enzymatic, fluorescence resonance energy transfer (FRET), surface enhanced Raman scattering, and optical sensing applications. This biosensing techniques lead to new and improved diagnostic procedures.

Photothermal therapies: Specific thermal exposure in tumoral regions is a promising therapy for different cancer types. This therapy can be enhanced with the use of gold nanoparticles that are targeted towards tumoral cells and increase their temperature when exposed to specific wavelengths.