Size & Size distribution
(Dynamic Ligh Scattering / Nanoparticle Tracking Analysis)
Ζ–Potential
M3-PALS (DLS)
Particle Concentration
Particle Concentration
(NTA)
Morphology Analysis (HR-TEM)
Morphology Analysis (HR-TEM)
Drug Loading & Entrapment Efficiency
Drug Loading & Entrapment Efficiency
Molecular/Element Analytical Methods
Molecular/Element Analytical Methods
Size & Size distribution
Size & Size distribution
- They are osmotically active and stable.
- They increase the stability of the entrapped drug
- Good solubilisation power
- Increased stability due to the surface electric charge
- Can increase the oral bioavailability of drugs
- Can enhance the skin penetration of drugs
- They can be used for oral, parenteral as well topical.
- Niosomesare biodegradable, biocompatible, and non-immunogenic.
- Improve the therapeutic performance of the drug by protecting it from the biological environment.
- Exhibit good colloidal, chemical and biological stability
Delivery of drug carriers to target cells by recognition of surface biomarkers is a promising approach with clear advantages. First, cellular specificity may reduce toxicity and keep adverse reactions to the minimum. Second, introduction of the cellular specificity may overcome the limitations of some previous therapies.
Nanoparticle interaction with cells and the cellular internalization machinery is quite complex and it has been challenging to identify unifying principles for particle internalization via specific pathways across cell types. Encapsulation of therapeutic agents into nanoparticles with a particular affinity for an internalization pathway is potentially highly efficient mode of membrane targeting. However, most cells are not highly specialized to recognize particles alone as targets for selective uptake, with the exception of professional scavenging cells such as reticuloendothelial cells and macrophages.
Addition of targeting ligands with specificity for receptors, either protein, carbohydrate or lipid based, to nanoparticles is an ideal strategy for targeting of nanoparticles to particular cells and/or for reaching specific membrane encapsulated compartments in cells.
However, in some cases biological materials introduced into cells via endocytosis lose their biological activity due to acidic media. In these cases, the use of fusogenic liposomes are an alternative for the release of drugs. Specifically, is expected to become a highly useful tool for use in gene therapy. The high efficiency of this system is attributable to the fact that materials introduced by membrane fusion can escape lysosomal degradation and reach the cytoplasm in an intact form.
Ζ-Potential
Ζ–Potential
- Combine the advantages of nanocarriers and therapeutic agents
- Highly efficient loading of drugs
- Can target specific areas due to its surface molecules
- Have lower cytotoxicity than other nanovesicles
- Increase the physical stability in serum
- They are more sensitive to targeted cells
- Highly biocompatible
- Can be modificated to improve its efficiency
Delivery of drug carriers to target cells by recognition of surface biomarkers is a promising approach with clear advantages. First, cellular specificity may reduce toxicity and keep adverse reactions to the minimum. Second, introduction of the cellular specificity may overcome the limitations of some previous therapies.
Nanoparticle interaction with cells and the cellular internalization machinery is quite complex and it has been challenging to identify unifying principles for particle internalization via specific pathways across cell types. Encapsulation of therapeutic agents into nanoparticles with a particular affinity for an internalization pathway is potentially highly efficient mode of membrane targeting. However, most cells are not highly specialized to recognize particles alone as targets for selective uptake, with the exception of professional scavenging cells such as reticuloendothelial cells and macrophages.
Addition of targeting ligands with specificity for receptors, either protein, carbohydrate or lipid based, to nanoparticles is an ideal strategy for targeting of nanoparticles to particular cells and/or for reaching specific membrane encapsulated compartments in cells.
However, in some cases biological materials introduced into cells via endocytosis lose their biological activity due to acidic media. In these cases, the use of fusogenic liposomes are an alternative for the release of drugs. Specifically, is expected to become a highly useful tool for use in gene therapy. The high efficiency of this system is attributable to the fact that materials introduced by membrane fusion can escape lysosomal degradation and reach the cytoplasm in an intact form.
